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SAGE Publications, Journal of Dental Research, 6(90), p. 735-739

DOI: 10.1177/0022034510397614

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A Major Gene Effect Controls Resistance to Caries

Journal article published in 2011 by R. I. Werneck, F. P. Lázaro, A. Cobat, A. V. Grant, M. B. Xavier, L. Abel, A. Alcaïs, P. C. Trevilatto ORCID, M. T. Mira ORCID
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This paper is available in a repository.

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Abstract

Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, major gene effect controlling resistance to phenotype was detected. The frequency of the resistance allele “A” was 0.63; mean numbers of decayed teeth were 1.53 and 9.53 for genotypes AA/AB and BB, respectively. These results represent a step toward a description of the exact nature of the genetic risk factors controlling human susceptibility to caries.