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Oxford University Press, American Journal of Epidemiology, 2(177), p. 142-151, 2012

DOI: 10.1093/aje/kws200

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Endometrial Cancer Risk Factors by 2 Main Histologic Subtypes

Journal article published in 2012 by Hannah P. Yang, Nicolas Wentzensen, Britton Trabert, Gretchen L. Gierach, Ashley S. Felix, Marc J. Gunter ORCID, Albert Hollenbeck, Yikyung Park ORCID, Mark E. Sherman, Louise A. Brinton
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Abstract

On the basis of clinical and pathologic criteria, endometrial carcinoma has been distinguished as Types I (mainly endometrioid) and II (nonendometrioid). Limited data suggest that these subtypes have different risk factor profiles. The authors prospectively evaluated risk factors for Types I (n = 1,312) and II (n = 138) incident endometrial carcinoma among 114,409 women in the National Institutes of Health (NIH)-AARP Diet and Health Study (1995–2006). For individual risk factors, relative risks were estimated with Cox regression by subtype, and Pheterogeneity was assessed in case-case comparisons with Type I as the referent. Stronger relations for Type I versus Type II tumors were seen for menopausal hormone therapy use (relative risk (RR) of 1.18 vs. 0.84; Pheterogeneity = 0.01) and body mass index of ≥30 vs.