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American Association of Immunologists, The Journal of Immunology, 5(189), p. 2094-2098, 2012

DOI: 10.4049/jimmunol.1201639

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Cutting Edge: Lymphoid Tissue Inducer Cells Maintain Memory CD4 T Cells within Secondary Lymphoid Tissue

Journal article published in 2012 by David R. Withers ORCID, Fabrina M. Gaspal, Emma C. Mackley, Clare L. Marriott, Ewan A. Ross, Guillaume E. Desanti ORCID, Natalie A. Roberts, Andrea J. White, Adriana Flores-Langarica, Fiona M. McConnell, Graham Anderson, Peter J. L. Lane
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, we show that although primary CD4 T cell expansion is normal in RORγ-deficient mice, the persistence of memory CD4 T cells is RORγ-dependent. Furthermore, using bone marrow chimeric mice we demonstrate that LTi cells are the key RORγ-expressing cell type sufficient for memory CD4 T cell survival in the absence of persistent Ag. This effect was specific for CD4 T cells, as memory CD8 T cells survived equally well in the presence or absence of LTi cells. These data demonstrate a novel role for LTi cells, archetypal members of the innate lymphoid cell family, in supporting memory CD4 T cell survival in vivo.