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BMJ Publishing Group, BMJ, 7181(318), p. 433-434, 1999

DOI: 10.1136/bmj.318.7181.433

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Historical cohort study of in utero exposure to uterotonic drugs and cognitive function in young adult life

Journal article published in 1999 by H. T. Sorensen, Henrik Toft Sørensen, Kenneth J. Rothman ORCID, Matthew W. Gillman, Flemming Hald Steffensen, Peer Fischer, Svend Sabroe
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Udgivelsesdato: 1999-May ; #ENTITYSTARTX02022;OBJECTIVE: To examine whether in utero exposure to uterotonic drugs effects cognitive performance in draft-age men. #ENTITYSTARTX02022;DESIGN: Historical cohort study based on birth registry data and cognitive function measured during evaluations for military service. #ENTITYSTARTX02022;SUBJECTS: 4300 Danish conscripts born between 1973 and 1975. #ENTITYSTARTX02022;MAIN OUTCOME MEASURES: MEAN SCORE IN THE BOERGE PRIEN TEST OF COGNITIVE FUNCTION: score is the number of correct answers to 78 questions and correlates with the full scale intelligence quotient. #ENTITYSTARTX02022;RESULTS: The mean Boerge Prien score was similar for those exposed (n=1011) to uterotonic drugs and those not exposed (n=3289), 43.1 versus 42.9 after adjustment for confounders. #ENTITYSTARTX02022;CONCLUSION: Our data indicate that exposure to uterotonic drugs does not affect cognitive function 20 years later.