Dissemin is shutting down on January 1st, 2025

Published in

Taylor and Francis Group, JAK-STAT, 3(2), p. e26089

DOI: 10.4161/jkst.26089

Links

Tools

Export citation

Search in Google Scholar

JAK-STAT pathway inDrosophilamorphogenesis

Journal article published in 2013 by James Castelli-Gair Hombría ORCID, Sol Sotillos ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

One of the main contributions of Drosophila to the JAK-STAT field is the study of morphogenesis. JAK-STAT signaling controls the formation of many different structures through surprisingly different morphogenetic behaviors that include induction of cell rearrangements, invagination, folding of tissues, modulation of cell shape, and migration. This variability may be explained by the many transcription factors and signaling molecules STAT regulates at early stages of development. But is STAT just acting as an upstream inducer of morphogenesis or does it have a more direct role in controlling cell behaviors? Here we review what is known about how the canonical phosphorylation of STAT contributes to shaping the embryonic and imaginal structures.