Dissemin is shutting down on January 1st, 2025

Published in

Karger Publishers, Journal of Vascular Research, 5(28), p. 358-365, 1991

DOI: 10.1159/000158882

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Effect of Age on Rabbit Aortic Responses to Relaxant Endothelium-Dependent and Endothelium-Independent Agents

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The aim of this study was to evaluate the effects of aging on endothelium-dependent and endothelium-independent relaxation of rabbit thoracic aorta from New Zealand white rabbits aged 4–6 and 7–12 months. The contractile response to noradrenaline (NA) decreased with increasing age, but NA [EC<sub>50</sub>] did not vary significantly. Acetylcholine (Ach)-induced relaxation of aortic rings precontracted with NA [EC<sub>50</sub>] did not change significantly with increasing age. The relaxation induced by ATP of aortic rings, precontracted with NA [EC<sub>50</sub>], was signficantly greater in young than in adult rabbits. This difference between young and adult animals became more evident in aortic rings deprived of endothelium: in adult animals, the ATP-induced relaxation of aortic rings with endothelium was significantly greater than in the rings without endothelium. The endothelium-independent relaxation by sodium nitrite (NaNO<sub>2</sub>) at lower concentrations was significantly greater in young than in adult rabbit aortic rings precontracted with NA [EC<sub>50</sub>]. Concluding, the age-induced changes in vascular response in male New Zealand white rabbits are related to an impaired mechanism at smooth muscle level.