Published in

Karger Publishers, Hormone Research in Paediatrics, 3(61), p. 103-107, 2004

DOI: 10.1159/000075373

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Sequelae of Syndrome X in Children Born Small for Gestational Age

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

<i>Objective:</i> Low birth weight is associated with the presence of syndrome X in adults. We studied the components of this syndrome in prepubertal children born SGA (small for gestational age) and children born AGA (appropriate for gestational age). <i>Methods</i>: Twenty-nine SGA children, age (mean ± SD) 9.1 ± 1.1 years and 24 AGA children, age 9.0 ± 1.1 years were studied. Fasting serum lipid concentrations were determined. A hyperinsulinemic euglycemic clamp was performed to measure insulin sensitivity. Ambulatory monitoring was performed to obtain 24-hour recordings of blood pressure. <i>Results:</i> Prepubertal SGA children are less insulin sensitive and have a higher nighttime systolic blood pressure (SBP) after correction for BMI than children born AGA. No differences were found in lipid concentrations between the 2 groups. <i>Conclusions:</i> Not all components of syndrome X can yet be found in 9-year-old children born SGA; follow-up of this cohort is required.