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Springer Nature [academic journals on nature.com], Translational Psychiatry, 5(2), p. e117-e117, 2012

DOI: 10.1038/tp.2012.45

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Genome-wide association study of Alzheimer's disease

Journal article published in 2012 by M. I. Kamboh, S. G. Younkin, Kamboh Mi, R. L. Minster, Demirci Fy, X. Wang, V. S. Pankratz, A. J. Saykin, M. A. Pericak-Vance, Minster Rl, R. A. Sweet, O. L. Lopez, Carrasquillo Mm, F. Y. Demirci, M. M. Carrasquillo and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In addition to apolipoprotein E (APOE), recent large genome-wide association studies (GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7) for late-onset Alzheimer's disease (LOAD). However, the genetic effect attributable to known loci is about 50%, indicating that additional risk genes for LOAD remain to be identified. In this study, we have used a new GWAS data set from the University of Pittsburgh (1291 cases and 938 controls) to examine in detail the recently implicated nine new regions with Alzheimer's disease (AD) risk, and also performed a meta-analysis utilizing the top 1% GWAS single-nucleotide polymorphisms (SNPs) with P