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Wiley, Journal of Thrombosis and Haemostasis, (9), p. 162-167, 2011

DOI: 10.1111/j.1538-7836.2011.04300.x

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Nanoscale studies of protein-membrane interactions in blood clotting

Journal article published in 2011 by J. H. Morrissey, E. Tajkhorshid ORCID, C. M. Rienstra
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.