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Public Library of Science, PLoS ONE, 4(4), p. e5209, 2009

DOI: 10.1371/journal.pone.0005209

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Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.

Journal article published in 2009 by Da Bax, Se Little, Nathalie Gaspar, Lara Perryman, Lynley Marshall, Marta Viana-Pereira, Ta Jones, Rd Williams, Anita Grigoriadis, Gilles Vassal, Paul Workman, Denise Sheer ORCID, Rm Reis, Ad Pearson, Darren Hargrave ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Although paediatric high grade gliomas resemble their adult counterparts in many ways, there appear to be distinct clinical and biological differences. One important factor hampering the development of new targeted therapies is the relative lack of cell lines derived from childhood glioma patients, as it is unclear whether the well-established adult lines commonly used are representative of the underlying molecular genetics of childhood tumours. We have carried out a detailed molecular and phenotypic characterisation of a series of paediatric high grade glioma cell lines in comparison to routinely used adult lines.