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American Society for Microbiology, Journal of Virology, 24(86), p. 13795-13799, 2012

DOI: 10.1128/jvi.02174-12

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Development of Neurological Disease Is Associated with Increased Immune Activation in Simian Immunodeficiency Virus-Infected Macaques

Journal article published in 2012 by Que Dang, Sonya Whitted, Robert M. Goeken, Jason M. Brenchley, Kenta Masuda, Kenta Matsuda, Charles R. Brown, Bernard A. P. Lafont ORCID, Matthew F. Starost, Ranjini Iyengar, Ronald J. Plishka, Alicia Buckler-White, Vanessa M. Hirsch
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.