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American Society for Microbiology, Journal of Virology, 24(86), p. 13263-13271, 2012

DOI: 10.1128/jvi.00565-12

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Genomic and Phylogenetic Characterization of Brazilian Yellow Fever Virus Strains

Journal article published in 2012 by Marcio R. T. Nunes, Gustavo Palacios ORCID, Jedson Ferreira Cardoso, Livia C. Martins, Edivaldo C. Sousa, Clayton Pereira Silva de Lima, Daniele B. A. Medeiros, Nazir Savji, Aaloki Desai, Sueli G. Rodrigues, Valeria L. Carvalho, W. Ian Lipkin, Pedro F. C. Vasconcelos
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3′ noncoding region (3′NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.