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Oxford University Press (OUP), International Journal of Epidemiology, 3(43), p. 878-886

DOI: 10.1093/ije/dyt267

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Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Human leukocyte telomere length (LTL) decreases with age and shorter LTL has previously been associated with increased prospective mortality. However, it is not clear whether LTL merely marks the health status of an individual by its association with parameters of immune function, for example, or whether telomere shortening also contributes causally to lifespan variation in humans.