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Published in

Rockefeller University Press, Journal of Cell Biology, 4(190), p. 487-489, 2010

DOI: 10.1083/jcb.201007096

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HDM2 ERKs PCNA

Journal article published in 2010 by Hai Dang Nguyen ORCID, Anja-Katrin Bielinsky ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability and is associated with cell transformation.