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Public Library of Science, PLoS ONE, 8(5), p. e12395, 2010

DOI: 10.1371/journal.pone.0012395

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Immunogenic Profiling in Mice of a HIV/AIDS Vaccine Candidate (MVA-B) Expressing Four HIV-1 Antigens and Potentiation by Specific Gene Deletions

Journal article published in 2010 by Juan García-Arriaza, José Luis Nájera, Carmen E. Gómez, Carlos Oscar S. Sorzano ORCID, Mariano Esteban
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The immune parameters of HIV/AIDS vaccine candidates that might be relevant in protection against HIV-1 infection are still undefined. The highly attenuated poxvirus strain MVA is one of the most promising vectors to be use as HIV-1 vaccine. We have previously described a recombinant MVA expressing HIV-1 Env, Gag, Pol and Nef antigens from clade B (referred as MVA-B), that induced HIV-1-specific immune responses in different animal models and gene signatures in human dendritic cells (DCs) with immunoregulatory function.