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Elsevier, Journal of Biological Chemistry, 2(289), p. 680-695, 2014

DOI: 10.1074/jbc.m113.518365

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Disruption of the Coxsackievirus and Adenovirus Receptor-Homodimeric Interaction Triggers Lipid Microdomain- and Dynamin-dependent Endocytosis and Lysosomal Targeting*

Journal article published in 2013 by Sara Salinas, Charleine Zussy, Fabien Loustalot, Daniel Henaff, Guillermo Menendez, Penny E. Morton, Maddy Parsons, Giampietro Schiavo ORCID, Eric J. Kremer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: The coxsackievirus and adenovirus receptor (CAR) acts as a docking factor during infection. Results: Adenovirus fiber knob induces CAR internalization via a pathway involving lipid microdomain integrity, actin dynamics, and dynamin. Conclusion: In neurons, CAR is linked to endocytic pathways that could modulate its function or regulate viral infection. Significance: Learning how viruses use receptors to enter and spread in the nervous system. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.