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BMJ Publishing Group, Annals of the Rheumatic Diseases, 8(71), p. 1350-1354, 2012

DOI: 10.1136/annrheumdis-2011-200802

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Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort

Journal article published in 2012 by John Bowes, Pauline Ho, Edw Flynn, Faisal Ali, Helena Marzo-Ortega, Laura C. Coates, Rich B. Warren, Ross McManus, Anthony W. Ryan, David Kane, Eleanor Korendowych, Neil McHugh, Oliver FitzGerald ORCID, Jonathon Packham, Ann W. Morgan and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVE: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA. METHODS: 56 single nucleotide polymorphisms (SNPs) mapping to 41 genes previously reported as RA susceptibility loci were selected for investigation. PsA was defined as an inflammatory arthritis associated with psoriasis and subjects were recruited from the UK and Ireland. Genotyping was performed using the Sequenom MassArray platform and frequencies compared with data derived from large UK control collections. RESULTS: Significant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)