Dissemin is shutting down on January 1st, 2025

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Wiley Open Access, Annals of Clinical and Translational Neurology, 6(1), p. 423-432, 2014

DOI: 10.1002/acn3.68

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Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis

Journal article published in 2014 by Guillaume Bonnier, Alexis Roche, David Romascano, Samanta Simioni, Djalel Meskaldji, David Rotzinger ORCID, Ying-Chia Lin, Ying‐Chia Lin, A. Lin, Gloria Menegaz, Myriam Schluep, Renaud Du Pasquier ORCID, Tilman Johannes Sumpf, Jens Frahm, Jean-Philippe Thiran and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Introduction: In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-­radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in earlyrelapsing-­remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients.