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Elsevier, Neurobiology of Aging, 7(33), p. 1237-1252, 2012

DOI: 10.1016/j.neurobiolaging.2011.01.003

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Age and amyloid-related alterations in default network habituation to stimulus repetition

Journal article published in 2011 by Patrizia Vannini ORCID, Trey Hedden, John A. Becker, Caroline Sullivan, Deepti Putcha, Dorene Rentz, Keith A. Johnson, Reisa A. Sperling
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This paper is available in a repository.

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Abstract

The neural networks supporting encoding of new information are thought to decline with age, although mnemonic techniques such as repetition may enhance performance in older individuals. Accumulation of amyloid-β, one hallmark pathology of Alzheimer’s disease (AD), may contribute to functional alterations in memory networks measured with functional magnetic resonance imaging (fMRI) prior to onset of cognitive impairment. We investigated the effects of age and amyloid burden on fMRI activity in the default network and hippocampus during repetitive encoding.