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Springer, Neurochemical Research, 7(36), p. 1175-1185, 2011

DOI: 10.1007/s11064-011-0457-7

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Inositol 1,4,5-Trisphosphate Receptor Subtype-Specific Regulation of Calcium Oscillations

Journal article published in 2011 by Songbai Zhang, Nicolas Fritz ORCID, Cristian Ibarra, Per Uhlén
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Oscillatory fluctuations in the cytosolic concentration of free calcium ions (Ca(2+)) are considered a ubiquitous mechanism for controlling multiple cellular processes. Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R) are intracellular Ca(2+) release channels that mediate Ca(2+) release from endoplasmic reticulum (ER) Ca(2+) stores. The three IP(3)R subtypes described so far exhibit differential structural, biophysical, and biochemical properties. Subtype specific regulation of IP(3)R by the endogenous modulators IP(3), Ca(2+), protein kinases and associated proteins have been thoroughly examined. In this article we will review the contribution of each IP(3)R subtype in shaping cytosolic Ca(2+) oscillations.