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SAGE Publications, Journal of Cerebral Blood Flow and Metabolism, 5(30), p. 895-899, 2010

DOI: 10.1038/jcbfm.2010.27

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Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats

Journal article published in 2010 by Tiziana Liistro, Letizia Guiducci ORCID, Silvia Burchielli, Daniele Panetta, Nicola Belcari, Silvia Pardini, Alberto Del Guerra, Piero A. Salvadori, Patricia Iozzo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with 18F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading.