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SAGE Publications, Journal of Cerebral Blood Flow and Metabolism, 2(30), p. 267-272, 2009

DOI: 10.1038/jcbfm.2009.217

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Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Journal article published in 2009 by Barry W. McColl ORCID, Nicola Rose, Fiona H. Robson, Nancy J. Rothwell, Catherine B. Lawrence
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese ( ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood–brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke.