Dissemin is shutting down on January 1st, 2025

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Mary Ann Liebert, Thyroid, 12(23), p. 1600-1608, 2013

DOI: 10.1089/thy.2013.0194

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Effects of Prostaglandin F<sub>2α</sub>on Adipocyte Biology Relevant to Graves' Orbitopathy

Journal article published in 2013 by Mohd Shazli Draman, Fiona Grennan-Jones, Lei Zhang, Peter N. Taylor, Tommy Kyaw Tun, John McDermott, Paul Moriarty, Daniel Morris, Carol Lane, Seamus Sreenan, Colin Dayan ORCID, Marian Ludgate ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Background: In Graves' orbitopathy (GO), increased proliferation, excess adipogenesis, and hyaluronan overproduction produce GO exophthalmos. Enophthalmos occurs in some glaucoma patients treated with Bimatoprost (prostaglandin F2α, PGF2α) eye drops. We hypothesized that enophthalmos is secondary to reductions in orbital tissue proliferation, adipogenesis, and/or increased lipolysis. We aimed to determine which of these is affected by PGF2α by using the 3T3-L1 murine preadipocyte cell line and primary human orbital fibroblasts (OFs) from GO patients (n=5) and non-GO (n=5).