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American Society for Clinical Investigation, Journal of Clinical Investigation, 9(122), p. 3046-3048

DOI: 10.1172/jci65483

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The attachment disorders of muscle: failure to carb-load

Journal article published in 2012 by Elizabeth M. McNally ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dystroglycan is a prominent cell surface protein that mediates attachment to the extracellular matrix. Although broadly expressed, glycosylated dystroglycan is critically important for muscle cell adherence to its surrounding matrix. A subgroup of muscular dystrophies, which often manifest in infancy, is associated with reduced glycosylation of dystroglycan. In this issue of the JCI, Beedle et al. used conditional gene targeting of Fktn, the gene responsible for Fukuyama congenital muscular dystrophy, to investigate a developmental requirement for glycosylation of dystroglycan.