Published in

Nature Research, Nature Genetics, 5(40), p. 546-552, 2008

DOI: 10.1038/ng.134

Links

Tools

Export citation

Search in Google Scholar

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

Journal article published in 2008 by Enrico Petretto, Rizwan Sarwar, Ian Grieve, Han Lu, Mande K. Kumaran, Phillip J. Muckett, Jonathan Mangion, Blanche Schroen, Matthew Benson, Prakash P. Punjabi, Sanjay K. Prasad, Dudley J. Pennell, Chris Kiesewetter, Elena S. Tasheva, Lolita M. Corpuz and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript2 (QTT) analyses of the cardiac transcriptome in the rat. Using these methods and in vitro functional assays, we identified osteoglycin (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM. We also applied genome-wide QTT analysis to the human heart and observed that, out of ~22,000 transcripts, OGN transcript abundance had the highest correlation with LVM. We further confirmed a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice. Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.