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Bentham Open, Open Virology Journal, 1(6), p. 216-231

DOI: 10.2174/1874357901206010216

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A Decade of Global mRNA and miRNA Profiling of HPV-Positive Cell Lines and Clinical Specimens

Journal article published in 2012 by Marya Morevati, Maria Rossing, Bodil Norrild, Bogumil Kaczkowski ORCID, Finn Cilius
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

For more than a decade, global gene expression profiling has been extensively used to elucidate the biology of human papillomaviruses (HPV) and their role in cervical- and head-and-neck cancers. Since 2008, the expression profiling of miRNAs has been reported in multiple HPV studies. Two major strategies have been employed in the gene and miRNA profiling studies: In the first approach, HPV positive tumors were compared to normal tissues or to HPV negative tumors. The second strategy relied on analysis of cell cultures transfected with single HPV oncogenes or with HPV genomes compared to untransfected cells considered as models for the development of premalignant and malignant transformations.