Published in

American Society for Clinical Investigation, Journal of Clinical Investigation, 9(120), p. 3064-3072, 2010

DOI: 10.1172/jci43085

Links

Tools

Export citation

Search in Google Scholar

Glaucoma: genes, phenotypes, and new directions for therapy

Journal article published in 2010 by Bao Jian Fan ORCID, Janey L. Wiggs
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Glaucoma, a leading cause of blindness worldwide, is characterized by progressive optic nerve damage, usually associated with intraocular pressure. Although the clinical progression of the disease is well defined, the molecular events responsible for glaucoma are currently poorly understood and current therapeutic strategies are not curative. This review summarizes the human genetics and genomic approaches that have shed light on the complex inheritance of glaucoma genes and the potential for gene-based and cellular therapies that this research makes possible.