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National Institute of Environmental Health Sciences (NIEHS), Environmental Health Perspectives, 5(123), p. 484-492, 2015

DOI: 10.1289/ehp.1408302

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E2F1-Mediated FOS Induction in Arsenic Trioxide–Induced Cellular Transformation: Effects of Global H3K9 Hypoacetylation and Promoter-Specific Hyperacetylation in Vitro

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Aberrant histone acetylation has been observed in carcinogenesis and cellular transformation associated with arsenic exposure; however, the molecular mechanisms and cellular outcomes of such changes are poorly understood.