Published in

Elsevier, Journal of Affective Disorders, 2-3(141), p. 294-299

DOI: 10.1016/j.jad.2012.03.035

Links

Tools

Export citation

Search in Google Scholar

Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss.

Journal article published in 2012 by Karen Ritchie, Isabelle Jaussent, Florence Portet, Philippe Courtet, Alain Malafosse, Jerome Maller, Chantal Meslin, Nicolas Menjot de Champfleur, Alain Bonafé, Emmanuelle Le Bars, Emmanuelle Le Bars, Sylvaine Artero, Marie-Laure Ancelin ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.