Published in

Physicians Postgraduate Press, Journal of Clinical Psychiatry, 04(73), p. e561-e566

DOI: 10.4088/jcp.10m06504

Elsevier, Year Book of Psychiatry and Applied Mental Health, (2013), p. 289-290

DOI: 10.1016/j.ypsy.2012.08.004

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Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United States.

Journal article published in 2012 by Bruno Etain, Mohamed Lajnef, Frank Bellivier, Flavie Mathieu, Aurélie Raust, Barbara Cochet, Sébastien Gard, Katia M'Bailara, Katia M’Bailara, Jean-Pierre Kahn, Orly Elgrabli, Renaud Cohen, Stéphane Jamain, Eduard Vieta, Marion Leboyer and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

BACKGROUND: The clinical presentation, course, and comorbidities of bipolar disorder type I are highly heterogeneous, and this variability remains poorly predictable. Certain onset characteristics (eg, age and polarity at onset) may delineate subgroups differing in clinical expression and outcome. METHOD: We retrospectively investigated the association between both age and polarity at onset and the clinical characteristics of bipolar I disorder (DSM-IV) in 2 independent adult samples: 480 French patients assessed in 1992-2006 (patients had been recruited from 3 university-affiliated psychiatry departments) and 714 US patients assessed in 1991-2003 (data were extracted from the Bipolar Disorder Phenome Database). RESULTS: Polarity at onset correlated with subsequent predominance (P