Published in
Physicians Postgraduate Press, Journal of Clinical Psychiatry, 04(73), p. e561-e566
DOI: 10.4088/jcp.10m06504
Elsevier, Year Book of Psychiatry and Applied Mental Health, (2013), p. 289-290
DOI: 10.1016/j.ypsy.2012.08.004
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Clinical Expression of Bipolar Disorder Type I as a Function of Age and Polarity at Onset
,
Aurélie Raust,
Barbara Cochet,
Sébastien Gard,
Katia M’Bailara,
Jean-Pierre Kahn,
Orly Elgrabli,
Renaud Cohen,
Stéphane Jamain,
Eduard Vieta,
Marion Leboyer,
Chantal Henry
Full text: Unavailable
Abstract
BACKGROUND: The clinical presentation, course, and comorbidities of bipolar disorder type I are highly heterogeneous, and this variability remains poorly predictable. Certain onset characteristics (eg, age and polarity at onset) may delineate subgroups differing in clinical expression and outcome. METHOD: We retrospectively investigated the association between both age and polarity at onset and the clinical characteristics of bipolar I disorder (DSM-IV) in 2 independent adult samples: 480 French patients assessed in 1992-2006 (patients had been recruited from 3 university-affiliated psychiatry departments) and 714 US patients assessed in 1991-2003 (data were extracted from the Bipolar Disorder Phenome Database). RESULTS: Polarity at onset correlated with subsequent predominance (P