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American Chemical Society, Journal of Medicinal Chemistry, 10(51), p. 2887-2890, 2008

DOI: 10.1021/jm8001444

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Discovery of Potent, Orally Bioavailable, Selective 5-HT<sub>1A/B/D</sub> Receptor Antagonists

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Preprint: archiving allowed
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Abstract

5-HT1 receptor antagonists have been discovered with good selectivity over the 5-HT transporter. This is the first report of highly potent, selective ligands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of molecules for further understanding the roles of the 5-HT1 receptor subtypes and providing new approaches,for the treatment of depression.