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American Society for Microbiology, Journal of Clinical Microbiology, 8(51), p. 2732-2734, 2013

DOI: 10.1128/jcm.00847-13

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Use of Vitek 2 Antimicrobial Susceptibility Profile To Identify mecC in Methicillin-Resistant Staphylococcus aureus

Journal article published in 2013 by Edward J. P. Cartwright, Gavin K. Paterson, Kathy E. Raven, Ewan M. Harrison, Theodore Gouliouris ORCID, Angela Kearns, Bruno Pichon, Giles Edwards, Robert L. Skov, Anders R. Larsen, Mark A. Holmes ORCID, Julian Parkhill ORCID, Sharon J. Peacock, Me Estée Török, M. Estée Török
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The emergence of mecC methicillin-resistant Staphylococcus aureus (MRSA) poses a diagnostic challenge for clinical microbiology laboratories. Using the Vitek 2 system, we tested a panel of 896 Staphylococcus aureus isolates and found that an oxacillin-sensitive/cefoxitin-resistant profile had a sensitivity of 88.7% and a specificity of 99.5% for the identification of mecC MRSA isolates. The presence of the mecC gene, determined by bacterial whole-genome sequencing, was used as the gold standard. This profile could provide a zero-cost screening method for identification of mecC -positive MRSA strains.