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American Society for Microbiology, Journal of Clinical Microbiology, 8(51), p. 2728-2731, 2013

DOI: 10.1128/jcm.00757-13

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Streptococcus sanguinis Isolate Displaying a Phenotype with Cross-Resistance to Several rRNA-Targeting Agents

Journal article published in 2013 by Rodrigo E. Mendes ORCID, Lalitagauri M. Deshpande, Jihye Kim, Debra S. Myers, James E. Ross, Ronald N. Jones
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT This study describes a clinical case of a 71-year-old male with a history of ischemic cardiomyopathy after left ventricular assist device (LVAD) endocarditis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) and a rare linezolid-resistant Streptococcus sanguinis strain (MIC, 32 μg/ml). The patient received courses of several antimicrobial agents, including linezolid for 79 days. The S. sanguinis strain had mutations in the 23S rRNA (T2211C, T2406C, G2576T, C2610T) and an amino acid substitution (N56D) in L22 and exhibited cross-resistance to ribosome-targeting agents.