Published in
MDPI, Hematology Reports, 2(5), p. e7, 2013
DOI: 10.4081/hr.2013.e7
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Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
,
Maria Chiara Abbenante,
Maria Chiara Abbenante,
Ilaria Iacobucci,
Alessandro Broccoli,
Claudia Venturi,
Nicoletta Testoni,
Anna Ferrari ,
Giovanni Martinelli
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Abstract
We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.