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Taylor and Francis Group, Critical Reviews in Toxicology, 3(45), p. 245-272, 2015

DOI: 10.3109/10408444.2014.999365

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Metabolism and metabolites of polychlorinated biphenyls

Journal article published in 2015 by Fabian A. Grimm, Dingfei Hu, Izabela Kania-Korwel, Hans-Joachim Lehmler ORCID, Gabriele Ludewig, Keri C. Hornbuckle, Michael W. Duffel, Åke Bergman, Larry W. Robertson
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Abstract

The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.