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American Society for Microbiology, Journal of Virology, 23(76), p. 12349-12354, 2002

DOI: 10.1128/jvi.76.23.12349-12354.2002

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Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides

Journal article published in 2002 by Jason J. Coull, Guocheng He, Christian Melander, Victor C. Rucker, Peter B. Dervan, David M. Margolis ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.