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Wiley, Proteomics: Clinical Applications, 5-6(9), p. 623-629, 2015

DOI: 10.1002/prca.201400198

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Circadian exosomal expression of renal thiazide-sensitive NaCl cotransporter (NCC) and prostasin in healthy individuals

Journal article published in 2015 by Annalisa Castagna, Francesca Pizzolo, Laura Chiecchi, Francesca Morandini, Sarath Kiran Channavajjhala, Patrizia Guarini, Gianluca Salvagno ORCID, Oliviero Olivieri
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

A circadian timing system is involved in the maintenance of fluid and electrolyte balance and blood pressure control. Aldosterone and vasopressin modulate ion transporters and channels crucial in sodium (Na) and water reabsorption such as the epithelium Na channel and the renal thiazide-sensitive NaCl cotransporter (NCC). We analyzed in urinary exosomes the intraday variations of NCC and prostasin expression and the association with electrolytes and water balance parameters.