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BioMed Central, Genome Medicine, 1(7), 2015

DOI: 10.1186/s13073-015-0182-y

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Impact of autoimmune risk alleles on the immune system

Journal article published in 2015 by John P. Ray ORCID, Nir Hacohen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune disease alter the human immune system, and suggest strategies for future autoimmune genetic research.