Published in
Wiley, Clinical Pharmacology & Therapeutics, 1(98), p. 87-95, 2015
DOI: 10.1002/cpt.104
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Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria
,
Sa A. McCormack,
Emmanuel Arinaitwe,
Victor Bigira,
Humphrey Wanzira,
Abel Kakuru ,
Jw W. Tappero,
Joel Tarning,
Niklas Lindegardh,
Francois Nosten,
Ft T. Aweeka,
Sunil Parikh
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Abstract
This prospective trial investigated the population pharmacokinetics of piperaquine given with dihydroartemisinin to treat uncomplicated malaria in 107 Ugandan children 6 months to 2 years old, an age group previously unstudied. Current weight-based dosing does not adequately address physiological changes in early childhood. Patients were administered standard 3-day oral doses and provided 1,282 capillary plasma concentrations from 218 malaria episodes. Less than 30% of treatments achieved 57 ng/mL on day 7. A three-compartment model with first-order absorption described the data well. Age had a statistically significant effect (P