A microfluidic dual gradient generator for conducting cell-based drug combination assays
Journal article published in 2016 by
Devrim Kilinc,
Jefrem Schwab,
Stefano Rampini,
Oshoke W. Ikpekha,
Ikpekha Ow,
Ashwin Thampi,
Agata Blasiak,
Peng Li,
Robert Schwamborn,
Walter Kolch,
David Matallanas 
,
Lee Gu,
Gil U. Lee
,
Lee Gu,
Gil U. Lee
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Abstract
We present a microfluidic gradient generator that exposes cultured cells to orthogonally-aligned linear concentration gradients of two molecules. Live-cell assays quantifying apoptotic signaling and cell motility are provided as proof-of-concept.