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American Society for Microbiology, Journal of Bacteriology, 14(188), p. 5299-5303, 2006

DOI: 10.1128/jb.00084-06

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Phosphate Starvation Induces the Sporulation Killing Factor of Bacillus subtilis

Journal article published in 2006 by Nicholas E. E. Allenby, Carys A. Watts, Georg Homuth, Zoltán Prágai, Anil Wipat, Alan C. Ward, Colin R. Harwood ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Bacillus subtilis produces and exports a peptide sporulation killing factor (SkfA) that induces lysis of sibling cells. skfA is part of the skf operon ( skfA-H ), which is responsible for immunity to SkfA, as well as for production and export of SkfA. Here we report that transcription of skfA is markedly induced when cells of B. subtilis are subjected to phosphate starvation. The role of PhoP in regulation of the skf operon was confirmed by in vitro gel shift assays, which showed that this operon is a new member of the PhoP regulon. A putative stem-loop structure in the skfA-skfB intergenic region is proposed to act as a stabilizer of an skfA -specific transcript.