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Wiley, Small, p. n/a-n/a

DOI: 10.1002/smll.201501178

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Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Journal article published in 2016 by Suresh Kumar Poovathingal ORCID, Nataly Kravchenko-Balasha, Young Shik Shin, Raphael David Levine, James R. Heath
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This paper is available in a repository.

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Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.