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American Society for Microbiology, Journal of Clinical Microbiology, 11(52), p. 4027-4029, 2014

DOI: 10.1128/jcm.02209-14

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Reassessment of Genotype 1 Hepatitis C Virus Subtype Misclassification by LiPA 2.0: Implications for Direct-Acting Antiviral Treatment

Journal article published in 2014 by Javier R. Guelfo, Juan Macias ORCID, Karin Neukam, Federico A. Di Lello, Federico A. DiLello, Jose A. Mira, Nicolas Merchante, María Mancebo, Rocío Nuñez-Torres, Juan A. Pineda, Luis M. Real
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The accuracy of LiPA 2.0 for hepatitis C virus 1 (HCV-1) subtype classification was analyzed. LiPA 2.0 genotype results from 101 HCV-1-infected patients were compared to genotype findings determined by direct core sequencing. Eleven (11%) samples were misclassified. Given the influence of the HCV-1-subtype in the anti-HCV therapy response, an alternative classification method is warranted.