Published in

Oxford University Press (OUP), The Journal of Infectious Diseases, 12(206), p. 1872-1877

DOI: 10.1093/infdis/jis610

Links

Tools

Export citation

Search in Google Scholar

Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients

Journal article published in 2012 by Su-Mi Choi, Hu Xie, Angela P. Campbell, Jane Kuypers, Wendy Leisenring ORCID, Alexandre A. Boudreault, Janet A. Englund, Lawrence Corey, Michael Boeckh
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus seasonal strains). Viremia increased the risk of progression to lower respiratory tract disease (LRD), hypoxemia, respiratory failure, and overall and influenza-related death. Among patients with LRD, viremia was associated with increased hazards of overall and influenza-associated death (hazard ratio 3.5, 1.1–12). Thus, influenza viremia may serve as marker for overall poor outcome.