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American Society for Microbiology, Journal of Virology, 24(87), p. 13889-13891, 2013

DOI: 10.1128/jvi.02458-13

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Surface Glycoproteins of an African Henipavirus Induce Syncytium Formation in a Cell Line Derived from an African Fruit Bat, Hypsignathus monstrosus

Journal article published in 2013 by Nadine Krüger, Markus Hoffmann, Michael Weis, Jan Felix Drexler ORCID, Marcel Alexander Müller, Christine Winter, Victor Max Corman ORCID, Tim Gützkow, Christian Drosten, Andrea Maisner, Georg Herrler
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus . Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.