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A crowd-sourcing approach for the construction of species-specific cell signaling networks
Journal article published in 2014 by
Erhan Bilal,
Theodore Sakellaropoulos,
Challenge Participants,
Ioannis N. Melas,
Dimitris E. Messinis,
Vincenzo Belcastro,
Kahn Rhrissorrakrai,
Pablo Meyer,
Raquel Norel 
,
Anita Iskandar ,
Elise Blaese,
Michael Biehl,
John J. Rice,
Manuel C. Peitsch ,
Julia Hoeng
and other authors.
,
Anita Iskandar ,
Elise Blaese,
Michael Biehl,
John J. Rice,
Manuel C. Peitsch ,
Julia Hoeng
and other authors.
Abstract
Motivation: Animal models are important tools in drug discovery and for understanding human biology in general. However, many drugs that initially show promising results in rodents fail in later stages of clinical trials. Understanding the commonalities and differences between human and rat cell signaling networks can lead to better experimental designs, improved allocation of resources and ultimately better drugs.