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BioMed Central, Arthritis Research and Therapy, 3(13), p. 221

DOI: 10.1186/ar3324

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Negative regulation of NF-κB and its involvement in rheumatoid arthritis

Journal article published in 2011 by Geert van Loo, Rudi Beyaert ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.