Dissemin is shutting down on January 1st, 2025

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BioMed Central, BMC Medicine, 1(12), 2014

DOI: 10.1186/1741-7015-12-34

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Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients

Journal article published in 2014 by Antonio López-Vázquez, Lourdes Mozo, Rebeca Alonso-Arias, Beatriz Suárez-Álvarez, José Ramón Vidal-Castiñeira, Eduardo Arranz, Umberto Volta, Carlos Bousoño, Marcos López-Hoyos, Luís Rodrigo ORCID, Carlos López-Larrea
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Overexpression of autologous proteins can lead to the formation of autoantibodies and autoimmune diseases. MHC class I polypeptide-related sequence A (MICA) is highly expressed in the enterocytes of patients with celiac disease, which arises in response to gluten. The aim of this study was to investigate anti-MICA antibody formation in patients with celiac disease and its association with other autoimmune processes. Methods We tested serum samples from 383 patients with celiac disease, obtained before they took up a gluten-free diet, 428 patients with diverse autoimmune diseases, and 200 controls for anti-MICA antibodies. All samples were also tested for anti-endomysium and anti-transglutaminase antibodies. Results Antibodies against MICA were detected in samples from 41.7% of patients with celiac disease but in only 3.5% of those from controls ( P