FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Álvarez, N.; von Smitten, K.; van der Schoot, E.; of Sohn, C.; Genica, Network; Ziegler, H.; van Brussel, T.; Gr, Australian Ovarian Cancer Study; Zatonski, W.; Wang, X.; Wang, Xianshu; Windebank, S. A.; Williams, E.; Wang, S.; Wolf, S.; Yon Dschun, K.; Webb, P.; Whiteman, D.; Yashiki, J.; Zaffaroni, D.; Wang, Qin; Yee, P. S.; Weerasooriya, N.; Meyer, K. B.; Van't Veer, Laura J.; Agarwal, Divianch; Silva, Idos S.; Tessier, D. C.; Michailidou, Kyriaki; Vincent, D.; Meyer, Kb; Herranz, J.; Robidoux, F.; Pita, G.; Pylkaes, K.; dos Santos Silva, I.; Moreno, Lt T.; Rutgers, E.; Swerdlow, Anthony; Verhoef, S.; Tnbcc,; Alonso, Mr R.; Siriwanarungsan, P.; Dennis, Joe; Schrauder, M.; Rübner, M.; Bolla, Mk K.; Jones, M.; Ryder Mills, E.; T.-C. Iau, P.; Sargus, K.; Rowan, A.; Menendez-Rodriguez, P.; Schneeweiss, A.; Hardisson, D.; Mendiola, M.; Sawyer, Elinor J.; Gonzalez-Neira, A.; Tomlinson, Ian; Lindblom, Annika; Real, F.; Margolin, Sara; Ashworth, Alan; Orr, Nick; Reynolds, P.; Investigators, KConFab; Matsuo, K.; Schmidt, Df F.; Rabstein, S.; Ito, H.; Southey, Mc C.; Thorne, H.; Iwata, H.; Teo, Sh H.; Park, Sk; Kondo, N.; Yip, Ch H.; Park, S. K.; Hartman, M.; Sivanandan, K.; Smeets, D.; Tay, Wt-T.; Hui, M.; Lim, Wy Y.; Scuvera, G.; Tranchant, M.; Shah, Mitul; Valois, M. F.; Kerin, Michael J.; Miller, Nicola; Kang, Diye; Turgeon, A.; Tchatchou, Sandrine; Choi, Jy-Y.; Sook Ye, Y.; Schmidt, Mk K.; Selander, T.; Szeszenia Dabrowska, N.; Noh, Dy-Y.; Stagner, M.; Rosenberg, Eh H.; Hopper, Jl L.; van't Veer, Lj J.; Rl, Milne; Renner, Sp P.; Reed, Mw W. R.; Makalic, E.; Meyer, Kb B.; Shen, Cy-Y.; Jones, Michael; Brauch, Hiltrud; Yu, Jc-C.; Brüning, Thomas; Park, Sk K.; Hamann, Ute; Bruening, T.; Dunning, Am M.; Wu, Ah H.; Park, S.; Andrulis, Il L.; Tseng, Cc-C.; Ben'itez, J.; Van Den Berg, D.; Berchuck, A.; Knight, Ja A.; Stram, Do O.; Glendon, G.; Eeles, R. A.; Amin Al Olama, A.; Broeks, Annegien; Kote Jarai, Z.; Stewart-Brown, S.; Fasching, Pa A.; Benlloch, S.; Siriwanarangsan, P.; Zheng, Wei; Group, Australian Ovarian Cancer Study; Ekici, Arif B.; Antoniou, A.; Beckmann, Mw W.; Iau, Pt T.-C.; Shrubsole, Mj J.; McGuffog, L.; Offit, K.; Shu, Xo-O.; Hsiung, Cn-N.; Lee, A.; Hou, M.-F.; Dicks, E.; Luccarini, C.; Zhang, Biao; Blot, W.; Radice, Paolo; Bacot, F.; Cai, Q.; Laboissière, S.; Nielsen, S. F.; Sangrajrang, S.; Cunningham, J. M.; Hilker, C. A.; Cox, Angela; Meyer, J.; Angelakos, M.; Toland, Ae E.; Brock, Iw W.; Yannoukakos, Drakoulis; Maskiell, J.; Muir, K.; Cornelissen, S.; Lophatananon, A.; Lt, Moreno; Silva, Id dos Santos; Hogervorst, F.; Boonyawongviroj, P.; Am, Dunning; Deming-Halverson, Sandra; Hein, A.; Truong, Thérèse; Pineda San Juan, Silvia; Long, Jirong; Sanchez, M.; Oeser, S.; Landrith, S.; Lu, W.; McInerney, N.; Gao, Yt-T.; Colleran, G.; Jones, A.; Bugert, P.; Tollenaar, Ra A. E. M.; Stegmaier, Christa; Peterlongo, Paolo; Osorio, A.; Manoukian, S.; Barroso, A.; Mariette, F.; Fernández, V.; González Niera, M.; Malats, N.; McKay, J.; Mr, Alonso; Couch, Fj J.; Herráez, B.; Yesilyurt, Bt T.; Díaz, E.; Miguel Martin, M.; Bernstein, L.; Fletcher, Olivia; Rudolph, Anja; Lacey, J.; Johnson, Nichola; Ma, H.; Seibold, P.; Marchand, Ll L.; Peto, Julian; Lu, Y.; Clague DeHart, J.; Marme, F.; Vachon, Celine; Deapen, D.; Burwinkel, Barbara; Pinder, R.; Guénel, P.; Lee, E.; Aittomaeki, K.; Severi, G.; Horn Ross, P.; Mulot, C.; Nelson, D.; Park, H.; Bojesen, Se E.; Schumacher, Frederick; Doerk, T.; Nordestgaard, Bg G.; Hermann, V.; Flyer, H.; Simard, Jacques; Fischer Bosch, M.; Lo, W. Y.; Brenner, Hermann; Justenhoven, C.; Dieffenbach, Ak K.; Arndt, Volker; Devillee, Peter; Winqvist, Robert; Baisch, C.; Mannermaa, Arto; Pylkäs, Katri; Fischer, H. P.; Kataja, Vesa; Df, Easton; Pesch, B.; Hartikainen, Jm M.; Mk, Bolla; Kosma, Veli-Matta; Lambrechts, Diether; Lotz, A.; Seynaeve, Caroline M.; Harth, V.; Floris, Guiseppe; Heikkinen, T.; Erkkilä, I.; Leunen, Karin; Aaltonene, K.; Antonenkova, N.; Chang-Claude, Jenny; Hillemanns, P.; Christiansen, H.; Flesch-Janys, Dieter; Myöhänen, E.; Olson, Je E.; Kemiläinen, H.; Niedermayr, E.; Botwell, D.; Pdp, Pharoah; Giles, Graham Gg; Tilanus-Linthorst, M.; Defazio, A.; Gertig, D.; Green, A.; Baglietto, Laura; Parsons, P.; Haiman, Ca A.; Hayward, N.; Fung, A.; Purrington, Kristen; Henderson, Be E.; Peuteman, G.; Corthouts, K.; Le Marchand, Loic; Obi, N.; Pharroah, Pd D. P.; Dumont, Martine; Heinz, J.; Goldberg, Mark S.; Behrens, S.; Eilber, U.; Labréche, France; Ji, Arias Perez; Celik, M.; Jukkola-Vuorinen, Arja; Olchers, T.; Peissel, B.; Grip, M.; Zamora, P.; Bonanni, B.; Devilee, P.; Barile, M.; Feroce, I.; E. M. Tollenaar, R. A.; García-Closas, Montserrat; Heguy, L.; Chanock, Sj J.; Kang, P.; Lissowska, Jolanta; Nee, K. I.; Figueroa, Jonine D.; Mariapun, S.; Czene, Kamila; Lee, D.; Eriksson, Mikael; Ching, T. Y.; Humphreys, Keith; Mohd Taib, N. A.; Darabi, Hartef; Dork, T.; Otsukka, M.; Hooning, Mj J.; Mononen, K.; Kriege, Mieke; Collee, Jm M.; Collée, Jm M.; Krol Warmerdam, E.; Molenaar, J.; Li, Jingmei; Blom, J.; Jakubowska, Anna; Brinton, L.; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Peplonska, B.; Chao, P.; Durda, Katarzyna; Nevanlinna, Heli; Bos, P.; Muranen, Ta A.; Crepin, E.; Aittomäki, Kristiina; Nieuwlaat, A.; Blomqvist, Carl; Heemskerk, A.; Bogdanova, Natalia; Dörk, Thilo; Higham, S.; Cross, S.; Hall, Per; Cramp, H.; Chenevix-Trench, Georgia; P. Pharoah, P. D.; Easton, Df F.; Conley, D.; Pharoah, Paul D. Pdp; Conroy, D.; ConFab Investigators, K.; Arias-Perez, Ji I.; Baynes, C.; Chua, K.; Benitez, J.; Benítez, Javier; Milne, Roger L.; Pilarski, R.

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FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Journal article published in 2014 by N. Álvarez, K. von Smitten, E. van der Schoot, C. of Sohn, Network Genica, H. Ziegler, T. van Brussel, Australian Ovarian Cancer Study Gr, W. Zatonski, X. Wang, Xianshu Wang, S. A. Windebank, E. Williams, S. Wang, S. Wolf and other authors.

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Abstract

Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. ; Agarwal, D Pineda, S Michailidou, K Herranz, J Pita, G Moreno, L T Alonso, M R Dennis, J Wang, Q Bolla, M K Meyer, K B Menendez-Rodriguez, P Hardisson, D Mendiola, M Gonzalez-Neira, A Lindblom, A Margolin, S Swerdlow, A Ashworth, A Orr, N Jones, M Matsuo, K Ito, H Iwata, H Kondo, N kConFab Investigators Australian Ovarian Cancer Study Group Hartman, M Hui, M Lim, W Y Iau, P T -C Sawyer, E Tomlinson, I Kerin, M Miller, N Kang, D Choi, J -Y Park, S K Noh, D -Y Hopper, J L Schmidt, D F Makalic, E Southey, M C Teo, S H Yip, C H Sivanandan, K Tay, W -T Brauch, H Bruning, T Hamann, U GENICA Network Dunning, A M Shah, M Andrulis, I L Knight, J A Glendon, G Tchatchou, S Schmidt, M K Broeks, A Rosenberg, E H van't Veer, L J Fasching, P A Renner, S P Ekici, A B Beckmann, M W Shen, C -Y Hsiung, C -N Yu, J -C Hou, M -F Blot, W Cai, Q Wu, A H Tseng, C -C Van Den Berg, D Stram, D O Cox, A Brock, I W Reed, M W R Muir, K Lophatananon, A Stewart-Brown, S Siriwanarangsan, P Zheng, W Deming-Halverson, S Shrubsole, M J Long, J Shu, X -O Lu, W Gao, Y -T Zhang, B Radice, P Peterlongo, P Manoukian, S Mariette, F Sangrajrang, S McKay, J Couch, F J Toland, A E Tnbcc Yannoukakos, D Fletcher, O Johnson, N dos Santos Silva, I Peto, J Marme, F Burwinkel, B Guenel, P Truong, T Sanchez, M Mulot, C Bojesen, S E Nordestgaard, B G Flyer, H Brenner, H Dieffenbach, A K Arndt, V Stegmaier, C Mannermaa, A Kataja, V Kosma, V -M Hartikainen, J M Lambrechts, D Yesilyurt, B T Floris, G Leunen, K Chang-Claude, J Rudolph, A Seibold, P Flesch-Janys, D Wang, X Olson, J E Vachon, C Purrington, K Giles, G G Severi, G Baglietto, L Haiman, C A Henderson, B E Schumacher, F Marchand, L Le Simard, J Dumont, M Goldberg, M S Labreche, F Winqvist, R Pylkas, K Jukkola-Vuorinen, A Grip, M Devilee, P Tollenaar, R A E M Seynaeve, C Garcia-Closas, M Chanock, S J Lissowska, J Figueroa, J D Czene, K Eriksson, M Humphreys, K Darabi, H Hooning, M J Kriege, M Collee, J M Tilanus-Linthorst, M Li, J Jakubowska, A Lubinski, J Jaworska-Bieniek, K Durda, K Nevanlinna, H Muranen, T A Aittomaki, K Blomqvist, C Bogdanova, N Dork, T Hall, P Chenevix-Trench, G Easton, D F Pharroah, P D P Arias-Perez, J I Zamora, P Benitez, J Milne, R L 1U19 CA148065/CA/NCI NIH HHS/United States 1U19 CA148112/CA/NCI NIH HHS/United States C1287/A10118/Cancer Research UK/United Kingdom C1287/A10710/Cancer Research UK/United Kingdom C1287/A12014/Cancer Research UK/United Kingdom C490/A10124/Cancer Research UK/United Kingdom CA098758/CA/NCI NIH HHS/United States CA128978/CA/NCI NIH HHS/United States CA132839/CA/NCI NIH HHS/United States CA54281/CA/NCI NIH HHS/United States CA63464/CA/NCI NIH HHS/United States CRN-87521/Canadian Institutes of Health Research/Canada P30 CA68485/CA/NCI NIH HHS/United States P50 CA116201/CA/NCI NIH HHS/United States R01 CA092447/CA/NCI NIH HHS/United States R01 CA122340/CA/NCI NIH HHS/United States R01 CA128978/CA/NCI NIH HHS/United States R01CA100374/CA/NCI NIH HHS/United States R01CA148667/CA/NCI NIH HHS/United States R01CA64277/CA/NCI NIH HHS/United States R37CA70867/CA/NCI NIH HHS/United States U19 CA148537/CA/NCI NIH HHS/United States UM1 CA164920/CA/NCI NIH HHS/United States Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England British journal of cancer Br J Cancer. 2014 Feb 18;110(4):1088-100. doi: 10.1038/bjc.2013.769.

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FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Abstract